Drug interactions
Diphenoxylate + Risperidone
Severity: Moderate
Diphenoxylate and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid antidiarrheal that can cause CNS depression, particularly in overdose or in children. Combined with risperidone, drowsiness and impaired alertness may increase.
What this interaction means in plain words
Diphenoxylate and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate belongs to Gastrointestinal Tract; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Monitor for sedation and keep to labeled doses. Counsel the patient on avoiding driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Diphenoxylate with Risperidone?
MediHelp rates the interaction as moderate. Diphenoxylate and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid antidiarrheal that can cause CNS depression, particularly in overdose or in children. Combined with risperidone, drowsiness and impaired alertness may increase.
How serious is the interaction between Diphenoxylate and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and keep to labeled doses. Counsel the patient on avoiding driving.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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