Drug interactions
Diphenoxylate-atropine + Hyoscyamine
Severity: Moderate
Diphenoxylate-atropine and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is the levorotatory form of atropine, so the combination is effectively duplicate antimuscarinic therapy. It can lead to dry mouth, urinary retention, constipation, blurred vision, tachycardia and confusion.
What this interaction means in plain words
Diphenoxylate-atropine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Avoid concurrent use where possible and monitor for anticholinergic toxicity, especially in older adults and those with urinary or bowel obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Diphenoxylate-atropine with Hyoscyamine?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is the levorotatory form of atropine, so the combination is effectively duplicate antimuscarinic therapy. It can lead to dry mouth, urinary retention, constipation, blurred vision, tachycardia and confusion.
How serious is the interaction between Diphenoxylate-atropine and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and monitor for anticholinergic toxicity, especially in older adults and those with urinary or bowel obstruction.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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