Drug interactions
Diphenoxylate-atropine + Risperidone
Severity: Moderate
Diphenoxylate-atropine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone causes sedation and has mild anticholinergic activity, adding to the opioid and atropine effects of diphenoxylate-atropine. Drowsiness, constipation, urinary retention and dizziness may increase.
What this interaction means in plain words
Diphenoxylate-atropine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for sedation, constipation and urinary retention, and use the antidiarrheal at the lowest effective dose for a limited time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Risperidone?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone causes sedation and has mild anticholinergic activity, adding to the opioid and atropine effects of diphenoxylate-atropine. Drowsiness, constipation, urinary retention and dizziness may increase.
How serious is the interaction between Diphenoxylate-atropine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, constipation and urinary retention, and use the antidiarrheal at the lowest effective dose for a limited time.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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