Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Leflunomide
Severity: Moderate
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide may blunt the immune response to this inactivated combination vaccine. Protection may be incomplete, but there is no infection risk from the vaccine.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antiproliferative immunosuppression may dampen humoral vaccine response.
What to do
Vaccinate when indicated, preferably before starting leflunomide; consider booster or serologic follow-up if protection is crucial.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Leflunomide?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide may blunt the immune response to this inactivated combination vaccine. Protection may be incomplete, but there is no infection risk from the vaccine.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when indicated, preferably before starting leflunomide; consider booster or serologic follow-up if protection is crucial.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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