Drug interactions
Diphtheria and tetanus toxoids + Leflunomide
Severity: Moderate
Diphtheria and tetanus toxoids and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide may reduce the antibody response to toxoid vaccines. Protection may be lower than expected, though these vaccines are not infectious.
What this interaction means in plain words
Diphtheria and tetanus toxoids and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antiproliferative immunosuppression may dampen humoral vaccine response.
What to do
Vaccination may proceed when indicated; ideally vaccinate before starting leflunomide and review immunity when needed, such as after wound exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids with Leflunomide?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide may reduce the antibody response to toxoid vaccines. Protection may be lower than expected, though these vaccines are not infectious.
How serious is the interaction between Diphtheria and tetanus toxoids and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination may proceed when indicated; ideally vaccinate before starting leflunomide and review immunity when needed, such as after wound exposure.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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