Drug interactions
Dipipanone + Propofol
Severity: Major
Dipipanone and Propofol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is a strong opioid analgesic, and with propofol it produces additive sedation, respiratory depression and hypotension. The risk of apnea and airway compromise increases.
What this interaction means in plain words
Dipipanone and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via mu-opioid agonism and GABA-A potentiation.
What to do
Lower and slowly titrate propofol doses, with continuous monitoring of ventilation, oxygenation and blood pressure. Ensure airway equipment and trained personnel are available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Propofol
Frequently asked questions
Can I take Dipipanone with Propofol?
MediHelp rates the interaction as major. Dipipanone and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid analgesic, and with propofol it produces additive sedation, respiratory depression and hypotension. The risk of apnea and airway compromise increases.
How serious is the interaction between Dipipanone and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower and slowly titrate propofol doses, with continuous monitoring of ventilation, oxygenation and blood pressure. Ensure airway equipment and trained personnel are available.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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