Drug interactions
Dipyridamole + Vortioxetine
Severity: Moderate
Dipyridamole and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, impairs platelet serotonin uptake and may increase bleeding risk. Combined with the antiplatelet action of dipyridamole, bleeding risk may be somewhat higher.
What this interaction means in plain words
Dipyridamole and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dipyridamole belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function: reduced platelet serotonin uptake with vortioxetine and inhibition of adenosine reuptake and platelet aggregation with dipyridamole.
What to do
Monitor for bruising, gastrointestinal or other bleeding, especially with additional antithrombotics or NSAIDs; consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Dipyridamole with Vortioxetine?
MediHelp rates the interaction as moderate. Dipyridamole and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, like other serotonergic antidepressants, impairs platelet serotonin uptake and may increase bleeding risk. Combined with the antiplatelet action of dipyridamole, bleeding risk may be somewhat higher.
How serious is the interaction between Dipyridamole and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, gastrointestinal or other bleeding, especially with additional antithrombotics or NSAIDs; consider gastroprotection in high-risk patients.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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