Drug interactions
Disopyramide + Glibenclamide
Severity: Moderate
Disopyramide and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia on its own, probably by stimulating insulin release. Combined with glyburide the risk of severe or prolonged low blood glucose is increased, particularly in older patients and in those with renal impairment.
What this interaction means in plain words
Disopyramide and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Glibenclamide belongs to Endocrine.
Why it happens
Additive hypoglycemic effect, with disopyramide thought to enhance insulin secretion; the mechanism is not fully established.
What to do
Monitor blood glucose closely when the combination is started and lower the glyburide dose if hypoglycemia occurs. Consider an alternative antiarrhythmic in patients at high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Disopyramide and Glibenclamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Glibenclamide?
MediHelp rates the interaction as moderate. Disopyramide and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause hypoglycemia on its own, probably by stimulating insulin release. Combined with glyburide the risk of severe or prolonged low blood glucose is increased, particularly in older patients and in those with renal impairment.
How serious is the interaction between Disopyramide and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when the combination is started and lower the glyburide dose if hypoglycemia occurs. Consider an alternative antiarrhythmic in patients at high risk.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
