Drug interactions
Disopyramide + Griseofulvin
Severity: Moderate
Disopyramide and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is cleared partly by CYP3A4, so induction can lower concentrations and reduce antiarrhythmic effect. The weak inducing effect of griseofulvin makes a meaningful change uncertain, but the narrow therapeutic index warrants awareness.
What this interaction means in plain words
Disopyramide and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Griseofulvin belongs to Anti Fungals.
Why it happens
Weak CYP3A4 induction by griseofulvin may increase disopyramide metabolism.
What to do
Monitor ECG and arrhythmia control, and check disopyramide concentrations where available when starting or stopping griseofulvin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Griseofulvin?
MediHelp rates the interaction as moderate. Disopyramide and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide is cleared partly by CYP3A4, so induction can lower concentrations and reduce antiarrhythmic effect. The weak inducing effect of griseofulvin makes a meaningful change uncertain, but the narrow therapeutic index warrants awareness.
How serious is the interaction between Disopyramide and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and arrhythmia control, and check disopyramide concentrations where available when starting or stopping griseofulvin.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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