Drug interactions
Disopyramide + Hydrocortisone
Severity: Minor
Disopyramide and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is metabolised by CYP3A4, which hydrocortisone may weakly induce. Corticosteroid-related hypokalemia may also raise proarrhythmic risk with disopyramide.
What this interaction means in plain words
Disopyramide and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Disopyramide belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction lowers disopyramide levels; steroid-induced hypokalemia adds a pharmacodynamic concern.
What to do
Monitor serum potassium and ECG during prolonged steroid therapy, and correct hypokalemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Hydrocortisone?
MediHelp rates the interaction as minor. Disopyramide and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disopyramide is metabolised by CYP3A4, which hydrocortisone may weakly induce. Corticosteroid-related hypokalemia may also raise proarrhythmic risk with disopyramide.
How serious is the interaction between Disopyramide and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during prolonged steroid therapy, and correct hypokalemia.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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