Drug interactions
Disopyramide + Indapamide
Severity: Major
Disopyramide and Indapamide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide prolongs the QT interval and can cause torsades de pointes, and indapamide-induced hypokalemia or hypomagnesemia increases that risk. The combination can lead to life-threatening arrhythmia.
What this interaction means in plain words
Disopyramide and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte depletion.
What to do
Monitor potassium, magnesium and ECG, and correct deficits promptly. Consider an alternative diuretic if disopyramide is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Indapamide
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Indapamide?
MediHelp rates the interaction as major. Disopyramide and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide prolongs the QT interval and can cause torsades de pointes, and indapamide-induced hypokalemia or hypomagnesemia increases that risk. The combination can lead to life-threatening arrhythmia.
How serious is the interaction between Disopyramide and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium and ECG, and correct deficits promptly. Consider an alternative diuretic if disopyramide is required.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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