Drug interactions
Disopyramide + Insulin aspart
Severity: Moderate
Disopyramide and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia, sometimes severe, and may add to the effect of insulin. Patients with diabetes, renal impairment or poor nutrition are at greater risk.
What this interaction means in plain words
Disopyramide and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Insulin aspart belongs to Endocrine.
Why it happens
Disopyramide may stimulate insulin secretion by blocking pancreatic ATP-sensitive potassium channels, adding to exogenous insulin effect.
What to do
Monitor blood glucose closely when starting disopyramide and reduce the insulin dose if needed. Teach patients to recognise hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Insulin aspart?
MediHelp rates the interaction as moderate. Disopyramide and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause hypoglycemia, sometimes severe, and may add to the effect of insulin. Patients with diabetes, renal impairment or poor nutrition are at greater risk.
How serious is the interaction between Disopyramide and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting disopyramide and reduce the insulin dose if needed. Teach patients to recognise hypoglycemia symptoms.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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