Drug interactions
Disopyramide + Insulin lispro
Severity: Moderate
Disopyramide and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia, sometimes severe, particularly in older patients or those with renal impairment or poor intake. It may add to the effect of insulin.
What this interaction means in plain words
Disopyramide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Insulin lispro belongs to Endocrine.
Why it happens
Disopyramide stimulates insulin release by blocking pancreatic KATP channels, adding to exogenous insulin.
What to do
Monitor blood glucose closely, especially in renal impairment. Reduce the insulin lispro dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Insulin lispro?
MediHelp rates the interaction as moderate. Disopyramide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause hypoglycemia, sometimes severe, particularly in older patients or those with renal impairment or poor intake. It may add to the effect of insulin.
How serious is the interaction between Disopyramide and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, especially in renal impairment. Reduce the insulin lispro dose if hypoglycemia occurs.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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