Drug interactions
Divalproex + Lomustine
Severity: Moderate
Divalproex and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause thrombocytopenia and myelosuppression, so their combination may deepen cytopenias and bleeding risk. Valproate may also modestly affect lomustine metabolism, but this is not well characterized.
What this interaction means in plain words
Divalproex and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression and thrombocytopenia; possible metabolic inhibition not well established.
What to do
Monitor complete blood counts, especially platelets, at regular intervals during treatment. Consider a non-valproate anticonvulsant if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Divalproex with Lomustine?
MediHelp rates the interaction as moderate. Divalproex and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause thrombocytopenia and myelosuppression, so their combination may deepen cytopenias and bleeding risk. Valproate may also modestly affect lomustine metabolism, but this is not well characterized.
How serious is the interaction between Divalproex and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts, especially platelets, at regular intervals during treatment. Consider a non-valproate anticonvulsant if cytopenias develop.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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