Drug interactions
Dobutamine + Fenfluramine
Severity: Moderate
Dobutamine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases serotonin release and can raise blood pressure, including pulmonary pressure, and heart rate. Combined with dobutamine it may add to cardiovascular stimulation, although the interaction is largely theoretical.
What this interaction means in plain words
Dobutamine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive cardiovascular stimulation from dobutamine beta agonism and fenfluramine serotonergic and sympathomimetic activity.
What to do
Monitor heart rate, blood pressure and rhythm during dobutamine infusion in patients taking fenfluramine. Adjust the infusion rate to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Dobutamine with Fenfluramine?
MediHelp rates the interaction as moderate. Dobutamine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine increases serotonin release and can raise blood pressure, including pulmonary pressure, and heart rate. Combined with dobutamine it may add to cardiovascular stimulation, although the interaction is largely theoretical.
How serious is the interaction between Dobutamine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and rhythm during dobutamine infusion in patients taking fenfluramine. Adjust the infusion rate to response.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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