Drug interactions
Dobutamine + Hydrochlorothiazide-irbesartan
Severity: Moderate
Dobutamine and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine can lower serum potassium through beta-2 mediated cellular uptake, adding to the potassium loss caused by hydrochlorothiazide. Hypokalemia can promote arrhythmias in patients receiving inotropic support.
What this interaction means in plain words
Dobutamine and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive hypokalemia from beta-adrenergic stimulation of cellular potassium uptake and thiazide-induced renal potassium loss.
What to do
Monitor serum potassium and ECG during dobutamine infusion and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Dobutamine and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine can lower serum potassium through beta-2 mediated cellular uptake, adding to the potassium loss caused by hydrochlorothiazide. Hypokalemia can promote arrhythmias in patients receiving inotropic support.
How serious is the interaction between Dobutamine and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dobutamine infusion and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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