Drug interactions
Dobutamine + Indacaterol
Severity: Moderate
Dobutamine and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine is a catecholamine inotrope with beta-1 agonist activity, and with indacaterol it can amplify heart rate and rhythm effects. This may provoke tachycardia, arrhythmia or hypokalemia, especially in patients with cardiovascular disease.
What this interaction means in plain words
Dobutamine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Additive adrenergic stimulation of cardiac beta receptors and beta-2 mediated potassium shift.
What to do
Monitor ECG, heart rate and blood pressure during dobutamine infusion in patients using indacaterol. Check potassium and consider withholding the inhaled dose during acute infusion if arrhythmia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Indacaterol?
MediHelp rates the interaction as moderate. Dobutamine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine is a catecholamine inotrope with beta-1 agonist activity, and with indacaterol it can amplify heart rate and rhythm effects. This may provoke tachycardia, arrhythmia or hypokalemia, especially in patients with cardiovascular disease.
How serious is the interaction between Dobutamine and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure during dobutamine infusion in patients using indacaterol. Check potassium and consider withholding the inhaled dose during acute infusion if arrhythmia occurs.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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