Drug interactions
Dobutamine + Ozanimod
Severity: Moderate
Dobutamine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, so sympathomimetic drugs may produce greater pressor effects. The labeling advises against combining it with drugs that raise norepinephrine. Dobutamine is a catecholamine metabolized mainly by COMT, so the actual risk is probably modest but hypertension is possible.
What this interaction means in plain words
Dobutamine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Ozanimod belongs to Central Nervous System.
Why it happens
MAO-B inhibition by the ozanimod metabolite may potentiate adrenergic effects.
What to do
Monitor blood pressure and heart rate closely when dobutamine is given to a patient on ozanimod, and titrate the infusion carefully. Consider alternatives if a hypertensive response occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Dobutamine with Ozanimod?
MediHelp rates the interaction as moderate. Dobutamine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, so sympathomimetic drugs may produce greater pressor effects. The labeling advises against combining it with drugs that raise norepinephrine. Dobutamine is a catecholamine metabolized mainly by COMT, so the actual risk is probably modest but hypertension is possible.
How serious is the interaction between Dobutamine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely when dobutamine is given to a patient on ozanimod, and titrate the infusion carefully. Consider alternatives if a hypertensive response occurs.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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