Drug interactions
Docetaxel + Fedratinib
Severity: Moderate
Docetaxel and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase docetaxel concentrations. This raises the risk of neutropenia, mucositis, neuropathy and fluid retention.
What this interaction means in plain words
Docetaxel and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing docetaxel metabolic clearance.
What to do
Monitor blood counts and docetaxel toxicity closely, and reduce the docetaxel dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Docetaxel with Fedratinib?
MediHelp rates the interaction as moderate. Docetaxel and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase docetaxel concentrations. This raises the risk of neutropenia, mucositis, neuropathy and fluid retention.
How serious is the interaction between Docetaxel and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and docetaxel toxicity closely, and reduce the docetaxel dose if adverse effects emerge.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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