Drug interactions
Docetaxel + Finerenone
Severity: Moderate
Docetaxel and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel is a weak CYP3A4 inhibitor and could modestly raise finerenone levels, increasing the risk of hyperkalemia. Chemotherapy-related renal effects may add to this risk.
What this interaction means in plain words
Docetaxel and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Finerenone belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition reduces finerenone metabolism, increasing exposure.
What to do
Monitor serum potassium and renal function during therapy and adjust finerenone dose if hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Docetaxel with Finerenone?
MediHelp rates the interaction as moderate. Docetaxel and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Docetaxel is a weak CYP3A4 inhibitor and could modestly raise finerenone levels, increasing the risk of hyperkalemia. Chemotherapy-related renal effects may add to this risk.
How serious is the interaction between Docetaxel and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during therapy and adjust finerenone dose if hyperkalemia occurs.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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