Drug interactions
Docetaxel + Fluconazole
Severity: Moderate
Docetaxel and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may raise docetaxel levels because docetaxel is cleared mainly by CYP3A4. Higher exposure could increase neutropenia, mucositis and other toxicities.
What this interaction means in plain words
Docetaxel and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4-mediated docetaxel metabolism.
What to do
Monitor blood counts and toxicity closely, and consider docetaxel dose reduction. Prefer a non-inhibiting antifungal if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Fluconazole?
MediHelp rates the interaction as moderate. Docetaxel and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may raise docetaxel levels because docetaxel is cleared mainly by CYP3A4. Higher exposure could increase neutropenia, mucositis and other toxicities.
How serious is the interaction between Docetaxel and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and toxicity closely, and consider docetaxel dose reduction. Prefer a non-inhibiting antifungal if feasible.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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