Drug interactions
Docetaxel + Fostamatinib
Severity: Moderate
Docetaxel and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite, tamatinib, inhibits P-glycoprotein and may increase docetaxel exposure. Docetaxel toxicity such as myelosuppression could be greater.
What this interaction means in plain words
Docetaxel and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Fostamatinib belongs to Oncology.
Why it happens
Tamatinib inhibits P-glycoprotein efflux, potentially raising docetaxel absorption and tissue levels.
What to do
Monitor blood counts and signs of docetaxel toxicity, and reduce the docetaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Docetaxel with Fostamatinib?
MediHelp rates the interaction as moderate. Docetaxel and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite, tamatinib, inhibits P-glycoprotein and may increase docetaxel exposure. Docetaxel toxicity such as myelosuppression could be greater.
How serious is the interaction between Docetaxel and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of docetaxel toxicity, and reduce the docetaxel dose if toxicity develops.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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