Drug interactions
Docetaxel + Nevirapine
Severity: Moderate
Docetaxel and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce docetaxel exposure and potentially lessen antitumor effect. Docetaxel is mainly cleared by CYP3A4, so induction is plausible, although data for nevirapine are limited.
What this interaction means in plain words
Docetaxel and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing docetaxel metabolism.
What to do
Monitor tumor response and toxicity, and consider a non-inducing antiretroviral regimen during docetaxel therapy where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Nevirapine?
MediHelp rates the interaction as moderate. Docetaxel and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce docetaxel exposure and potentially lessen antitumor effect. Docetaxel is mainly cleared by CYP3A4, so induction is plausible, although data for nevirapine are limited.
How serious is the interaction between Docetaxel and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and toxicity, and consider a non-inducing antiretroviral regimen during docetaxel therapy where feasible.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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