Drug interactions
Docetaxel + Stiripentol
Severity: Moderate
Docetaxel and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and may also induce CYP3A4 and can inhibit P-glycoprotein, so docetaxel exposure could change unpredictably, most likely increasing. Higher exposure may worsen myelosuppression and other docetaxel toxicities. Data are theoretical, and the effect is likely modest.
What this interaction means in plain words
Docetaxel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 activity and inhibits P-glycoprotein efflux, altering docetaxel clearance and distribution.
What to do
Monitor neutrophil counts and signs of docetaxel toxicity closely. Reduce the docetaxel dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Docetaxel and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Docetaxel
Other interactions of Stiripentol
Frequently asked questions
Can I take Docetaxel with Stiripentol?
MediHelp rates the interaction as moderate. Docetaxel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and may also induce CYP3A4 and can inhibit P-glycoprotein, so docetaxel exposure could change unpredictably, most likely increasing. Higher exposure may worsen myelosuppression and other docetaxel toxicities. Data are theoretical, and the effect is likely modest.
How serious is the interaction between Docetaxel and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of docetaxel toxicity closely. Reduce the docetaxel dose if adverse effects develop.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
