Drug interactions
Dolasetron + Ezogabine
Severity: Moderate
Dolasetron and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can prolong the QT interval, and dolasetron has a dose-related QT effect. Combined use may increase risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Dolasetron and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Ezogabine belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain baseline and follow-up ECG in patients with cardiac risk factors and correct electrolytes. Choose an alternative antiemetic if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Dolasetron with Ezogabine?
MediHelp rates the interaction as moderate. Dolasetron and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine can prolong the QT interval, and dolasetron has a dose-related QT effect. Combined use may increase risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Dolasetron and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECG in patients with cardiac risk factors and correct electrolytes. Choose an alternative antiemetic if risk is high.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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