Drug interactions
Dolasetron + Fluticasone-salmeterol
Severity: Moderate
Dolasetron and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron, through its active metabolite hydrodolasetron, prolongs PR, QRS and QT intervals. Salmeterol may add to QTc and heart rate effects, increasing arrhythmia risk in susceptible patients.
What this interaction means in plain words
Dolasetron and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive QTc prolongation from dolasetron metabolite and beta-2 agonist effects.
What to do
Correct potassium and magnesium and obtain an ECG in patients with cardiac risk factors. Consider a different antiemetic such as one with less QT effect if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Dolasetron and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron, through its active metabolite hydrodolasetron, prolongs PR, QRS and QT intervals. Salmeterol may add to QTc and heart rate effects, increasing arrhythmia risk in susceptible patients.
How serious is the interaction between Dolasetron and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and obtain an ECG in patients with cardiac risk factors. Consider a different antiemetic such as one with less QT effect if risk is high.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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