Drug interactions
Dolasetron + Frovatriptan
Severity: Moderate
Dolasetron and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on serotonergic pathways, and rare serotonin syndrome has been described when 5-HT3 antagonists are used with triptans. The risk is low but the reaction can be serious.
What this interaction means in plain words
Dolasetron and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Frovatriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic effects; not firmly established.
What to do
Monitor for agitation, tremor, hyperreflexia and hyperthermia when used together. Stop both and treat supportively if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Dolasetron with Frovatriptan?
MediHelp rates the interaction as moderate. Dolasetron and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on serotonergic pathways, and rare serotonin syndrome has been described when 5-HT3 antagonists are used with triptans. The risk is low but the reaction can be serious.
How serious is the interaction between Dolasetron and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia and hyperthermia when used together. Stop both and treat supportively if serotonin syndrome is suspected.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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