Drug interactions
Dolasetron + Imipramine
Severity: Moderate
Dolasetron and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rare serotonin syndrome has been reported with 5-HT3 antagonists and tricyclic antidepressants. Imipramine also slows cardiac conduction and can prolong QT, adding to dolasetron's ECG effects.
What this interaction means in plain words
Dolasetron and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Imipramine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects and additive prolongation of cardiac conduction and repolarization.
What to do
Monitor for serotonin toxicity and obtain an ECG in patients with heart disease or electrolyte abnormalities. Prefer another antiemetic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dolasetron with Imipramine?
MediHelp rates the interaction as moderate. Dolasetron and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rare serotonin syndrome has been reported with 5-HT3 antagonists and tricyclic antidepressants. Imipramine also slows cardiac conduction and can prolong QT, adding to dolasetron's ECG effects.
How serious is the interaction between Dolasetron and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and obtain an ECG in patients with heart disease or electrolyte abnormalities. Prefer another antiemetic in high-risk patients.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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