Drug interactions
Dolasetron + Lefamulin
Severity: Major
Dolasetron and Lefamulin: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and dolasetron adds to this effect. The risk of torsades de pointes is increased, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Dolasetron and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive QT interval prolongation.
What to do
Avoid the combination if an alternative antiemetic or antibiotic is available. If used together, check ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Dolasetron with Lefamulin?
MediHelp rates the interaction as major. Dolasetron and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin can prolong the QT interval, and dolasetron adds to this effect. The risk of torsades de pointes is increased, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Dolasetron and Lefamulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antiemetic or antibiotic is available. If used together, check ECG and correct potassium and magnesium.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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