Drug interactions
Dolasetron + Nortriptyline
Severity: Moderate
Dolasetron and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline can slow cardiac conduction and prolong QT, adding to dolasetron's ECG effects. Rare serotonin syndrome has also been reported with 5-HT3 antagonists and tricyclics.
What this interaction means in plain words
Dolasetron and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac conduction and repolarization, plus possible additive serotonergic effects.
What to do
Obtain an ECG in patients with cardiac disease or electrolyte abnormalities and monitor for serotonin toxicity. Consider another antiemetic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Dolasetron with Nortriptyline?
MediHelp rates the interaction as moderate. Dolasetron and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline can slow cardiac conduction and prolong QT, adding to dolasetron's ECG effects. Rare serotonin syndrome has also been reported with 5-HT3 antagonists and tricyclics.
How serious is the interaction between Dolasetron and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with cardiac disease or electrolyte abnormalities and monitor for serotonin toxicity. Consider another antiemetic in high-risk patients.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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