Drug interactions
Dolasetron + Pazopanib
Severity: Major
Dolasetron and Pazopanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can prolong the QT interval and cause torsades de pointes, and dolasetron adds to this effect. Risk is greater with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Dolasetron and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation through cardiac repolarization delay.
What to do
Use an antiemetic with less QT effect when possible. If combined, obtain baseline and periodic ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Dolasetron with Pazopanib?
MediHelp rates the interaction as major. Dolasetron and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib can prolong the QT interval and cause torsades de pointes, and dolasetron adds to this effect. Risk is greater with electrolyte disturbance or cardiac disease.
How serious is the interaction between Dolasetron and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antiemetic with less QT effect when possible. If combined, obtain baseline and periodic ECGs and correct potassium and magnesium.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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