Drug interactions
Dolasetron + Phenelzine
Severity: Major
Dolasetron and Phenelzine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported with 5-HT3 antagonists in patients receiving serotonergic drugs, and MAO inhibitors carry the highest risk. The combination could precipitate a severe reaction.
What this interaction means in plain words
Dolasetron and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Phenelzine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects in the setting of irreversible MAO inhibition.
What to do
Prefer an antiemetic from a different class in patients taking an MAO inhibitor. If combined, monitor closely for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Nardil 15 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: 5HT3 antagonists; "Methylthioninium chloride and 5HT3 antagonists should also be avoided.") — electronic medicines compendium (UK SmPC)
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Dolasetron with Phenelzine?
MediHelp rates the interaction as major. Dolasetron and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Serotonin syndrome has been reported with 5-HT3 antagonists in patients receiving serotonergic drugs, and MAO inhibitors carry the highest risk. The combination could precipitate a severe reaction.
How serious is the interaction between Dolasetron and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic from a different class in patients taking an MAO inhibitor. If combined, monitor closely for serotonin toxicity.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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