Drug interactions
Dolasetron + Rasagiline
Severity: Moderate
Dolasetron and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a 5-HT3 antagonist with an MAO-B inhibitor has been associated with serotonin syndrome in labeling and case reports, though the risk is considered modest. Features include agitation, tremor, hyperreflexia, sweating, and fever.
What this interaction means in plain words
Dolasetron and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Rasagiline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect from MAO inhibition together with 5-HT3 antagonism; the mechanism is not firmly established.
What to do
Monitor for signs of serotonin toxicity when starting or changing doses. Stop both drugs and treat supportively if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dolasetron and Rasagiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dolasetron with Rasagiline?
MediHelp rates the interaction as moderate. Dolasetron and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a 5-HT3 antagonist with an MAO-B inhibitor has been associated with serotonin syndrome in labeling and case reports, though the risk is considered modest. Features include agitation, tremor, hyperreflexia, sweating, and fever.
How serious is the interaction between Dolasetron and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity when starting or changing doses. Stop both drugs and treat supportively if symptoms appear.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
