Drug interactions
Dolasetron + Salbutamol
Severity: Moderate
Dolasetron and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron prolongs the PR, QRS and QT intervals, and salbutamol may add to QT effects and lower potassium. The combination can increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Dolasetron and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia contributing.
What to do
Check ECG and correct potassium and magnesium when salbutamol is used at high doses with dolasetron. Consider an alternative antiemetic in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Salbutamol?
MediHelp rates the interaction as moderate. Dolasetron and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron prolongs the PR, QRS and QT intervals, and salbutamol may add to QT effects and lower potassium. The combination can increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Dolasetron and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium when salbutamol is used at high doses with dolasetron. Consider an alternative antiemetic in patients with QT risk factors.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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