Drug interactions
Dolutegravir + Empagliflozin-metformin
Severity: Moderate
Dolutegravir and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir raises metformin exposure, increasing the potential for metformin adverse effects including gastrointestinal intolerance and lactic acidosis. The effect is clinically relevant at higher metformin doses.
What this interaction means in plain words
Dolutegravir and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Dolutegravir inhibits renal OCT2 and MATE1 transporters, reducing metformin renal clearance.
What to do
Limit the total daily metformin dose to 1,000 mg when used with dolutegravir, and monitor blood glucose and renal function when starting or stopping dolutegravir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Dolutegravir and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolutegravir raises metformin exposure, increasing the potential for metformin adverse effects including gastrointestinal intolerance and lactic acidosis. The effect is clinically relevant at higher metformin doses.
How serious is the interaction between Dolutegravir and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the total daily metformin dose to 1,000 mg when used with dolutegravir, and monitor blood glucose and renal function when starting or stopping dolutegravir.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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