Drug interactions
Dolutegravir + Ferrous gluconate
Severity: Moderate
Dolutegravir and Ferrous gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron binds dolutegravir in the gastrointestinal tract and can substantially reduce its absorption. This may cause subtherapeutic levels and virologic failure.
What this interaction means in plain words
Dolutegravir and Ferrous gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Ferrous gluconate belongs to Miscellaneous.
Why it happens
Chelation of dolutegravir by ferrous iron in the gut reduces absorption.
What to do
Take dolutegravir 2 hours before or 6 hours after iron, or take both together with a meal; monitor viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Other interactions of Ferrous gluconate
Frequently asked questions
Can I take Dolutegravir with Ferrous gluconate?
MediHelp rates the interaction as moderate. Dolutegravir and Ferrous gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron binds dolutegravir in the gastrointestinal tract and can substantially reduce its absorption. This may cause subtherapeutic levels and virologic failure.
How serious is the interaction between Dolutegravir and Ferrous gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir 2 hours before or 6 hours after iron, or take both together with a meal; monitor viral load.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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