Drug interactions
Dolutegravir + Glipizide-metformin
Severity: Moderate
Dolutegravir and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir inhibits renal transporters OCT2 and MATE1, reducing metformin elimination and substantially increasing metformin exposure. This raises the risk of metformin adverse effects, including gastrointestinal intolerance and lactic acidosis.
What this interaction means in plain words
Dolutegravir and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Glipizide-metformin belongs to Endocrine.
Why it happens
Inhibition of renal tubular secretion of metformin via OCT2 and MATE1.
What to do
Limit the total daily metformin dose to 1,000 mg when used with dolutegravir and monitor blood glucose and renal function. Re-adjust metformin when dolutegravir is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dolutegravir and Glipizide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Glipizide-metformin?
MediHelp rates the interaction as moderate. Dolutegravir and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolutegravir inhibits renal transporters OCT2 and MATE1, reducing metformin elimination and substantially increasing metformin exposure. This raises the risk of metformin adverse effects, including gastrointestinal intolerance and lactic acidosis.
How serious is the interaction between Dolutegravir and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the total daily metformin dose to 1,000 mg when used with dolutegravir and monitor blood glucose and renal function. Re-adjust metformin when dolutegravir is stopped.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
