Drug interactions
Dolutegravir + Glyburide-metformin
Severity: Moderate
Dolutegravir and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir raises metformin exposure by blocking its renal and hepatic transporters, which can increase the risk of metformin adverse effects including gastrointestinal intolerance and lactic acidosis. The effect is clinically meaningful at usual metformin doses.
What this interaction means in plain words
Dolutegravir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Glyburide-metformin belongs to Endocrine.
Why it happens
Dolutegravir inhibits OCT2 and MATE1 transporters, decreasing renal tubular secretion of metformin.
What to do
Limit the total daily metformin dose to about 1,000 mg when starting either drug, and monitor glucose and renal function. Re-evaluate the metformin dose when dolutegravir is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Glyburide-metformin?
MediHelp rates the interaction as moderate. Dolutegravir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolutegravir raises metformin exposure by blocking its renal and hepatic transporters, which can increase the risk of metformin adverse effects including gastrointestinal intolerance and lactic acidosis. The effect is clinically meaningful at usual metformin doses.
How serious is the interaction between Dolutegravir and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the total daily metformin dose to about 1,000 mg when starting either drug, and monitor glucose and renal function. Re-evaluate the metformin dose when dolutegravir is stopped.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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