Drug interactions
Dolutegravir + Metformin-pioglitazone
Severity: Moderate
Dolutegravir and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir inhibits renal OCT2 and MATE1, which increases metformin exposure substantially. This raises the risk of metformin adverse effects, including gastrointestinal intolerance and, rarely, lactic acidosis.
What this interaction means in plain words
Dolutegravir and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Inhibition of renal tubular transporters OCT2 and MATE1 reduces metformin elimination.
What to do
Limit the total daily metformin dose to about 1,000 mg when co-administered, and monitor glucose and renal function. Re-adjust the metformin dose if dolutegravir is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Dolutegravir and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolutegravir inhibits renal OCT2 and MATE1, which increases metformin exposure substantially. This raises the risk of metformin adverse effects, including gastrointestinal intolerance and, rarely, lactic acidosis.
How serious is the interaction between Dolutegravir and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the total daily metformin dose to about 1,000 mg when co-administered, and monitor glucose and renal function. Re-adjust the metformin dose if dolutegravir is stopped.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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