Drug interactions
Dolutegravir + Metformin-repaglinide
Severity: Moderate
Dolutegravir and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir inhibits renal OCT2 and MATE1 transporters, which reduces metformin clearance and raises metformin exposure. This increases the risk of metformin adverse effects, including lactic acidosis, particularly in renal impairment.
What this interaction means in plain words
Dolutegravir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of OCT2 and MATE1-mediated renal tubular secretion of metformin by dolutegravir.
What to do
Limit the total daily metformin dose to 1,000 mg when starting either drug, and reassess the metformin dose when dolutegravir is stopped. Monitor blood glucose and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Dolutegravir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolutegravir inhibits renal OCT2 and MATE1 transporters, which reduces metformin clearance and raises metformin exposure. This increases the risk of metformin adverse effects, including lactic acidosis, particularly in renal impairment.
How serious is the interaction between Dolutegravir and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the total daily metformin dose to 1,000 mg when starting either drug, and reassess the metformin dose when dolutegravir is stopped. Monitor blood glucose and renal function.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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