Drug interactions
Dolutegravir + Orlistat
Severity: Moderate
Dolutegravir and Orlistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat has been linked to loss of virological control in people on antiretrovirals, possibly via reduced absorption. Lower dolutegravir levels could lead to viral rebound and resistance.
What this interaction means in plain words
Dolutegravir and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Orlistat belongs to Miscellaneous.
Why it happens
Orlistat may reduce gastrointestinal absorption of dolutegravir; the mechanism is not clearly established.
What to do
Avoid orlistat if possible, or monitor HIV RNA frequently and stop orlistat if viral load rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Other interactions of Orlistat
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
Frequently asked questions
Can I take Dolutegravir with Orlistat?
MediHelp rates the interaction as moderate. Dolutegravir and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat has been linked to loss of virological control in people on antiretrovirals, possibly via reduced absorption. Lower dolutegravir levels could lead to viral rebound and resistance.
How serious is the interaction between Dolutegravir and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid orlistat if possible, or monitor HIV RNA frequently and stop orlistat if viral load rises.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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