Drug interactions
domperidone + rabeprazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
PPI-induced hypomagnesemia can increase the risk of domperidone-related QT prolongation and ventricular arrhythmias.
Mechanism of action
PPIs may lower magnesium; electrolyte disturbances potentiate QT-prolonging effects of domperidone.
Clinical management
Assess baseline and periodic Mg and K, especially with prolonged PPI use; correct abnormalities; use minimal effective domperidone dose/duration; consider ECG monitoring if additional risk factors.
Drug reference
References
- AcipHex (rabeprazole) Prescribing Information – Hypomagnesemia warning — FDA Label
- Domperidone (Motilium) – Summary of Product Characteristics: Cardiac effects/QT prolongation — EMA
- Domperidone: small risk of serious cardiac side effects – restrictions and contraindications (2014) — MHRA
Frequently asked questions
Can I take domperidone with rabeprazole?
The interaction is rated: Moderate. PPI-induced hypomagnesemia can increase the risk of domperidone-related QT prolongation and ventricular arrhythmias.
How serious is the interaction between domperidone and rabeprazole?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between domperidone and rabeprazole managed?
Assess baseline and periodic Mg and K, especially with prolonged PPI use; correct abnormalities; use minimal effective domperidone dose/duration; consider ECG monitoring if additional risk factors.
Why do domperidone and rabeprazole interact?
PPIs may lower magnesium; electrolyte disturbances potentiate QT-prolonging effects of domperidone.
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