Drug interactions
Donepezil + Posaconazole
Severity: Moderate
Donepezil and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and posaconazole can prolong the QT interval, and donepezil has been associated with torsades de pointes. Posaconazole may also modestly raise donepezil exposure through CYP3A4 inhibition.
What this interaction means in plain words
Donepezil and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition raising donepezil levels.
What to do
Check baseline ECG and electrolytes, and monitor QTc and heart rate. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Posaconazole?
MediHelp rates the interaction as moderate. Donepezil and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both donepezil and posaconazole can prolong the QT interval, and donepezil has been associated with torsades de pointes. Posaconazole may also modestly raise donepezil exposure through CYP3A4 inhibition.
How serious is the interaction between Donepezil and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor QTc and heart rate. Avoid adding other QT-prolonging drugs.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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