Drug interactions
Donepezil + Prochlorperazine
Severity: Moderate
Donepezil and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and donepezil has been linked to torsades de pointes. Donepezil can also worsen or oppose antipsychotic effects and phenothiazines may reduce cholinergic benefit and aggravate extrapyramidal symptoms.
What this interaction means in plain words
Donepezil and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus pharmacodynamic opposition between cholinesterase inhibition and dopamine or muscarinic blockade.
What to do
Check ECG and electrolytes in patients with other QT risk factors. Monitor for bradycardia, extrapyramidal symptoms and reduced cognitive benefit.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Prochlorperazine?
MediHelp rates the interaction as moderate. Donepezil and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and donepezil has been linked to torsades de pointes. Donepezil can also worsen or oppose antipsychotic effects and phenothiazines may reduce cholinergic benefit and aggravate extrapyramidal symptoms.
How serious is the interaction between Donepezil and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with other QT risk factors. Monitor for bradycardia, extrapyramidal symptoms and reduced cognitive benefit.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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