Drug interactions
Dopamine + Hydralazine
Severity: Moderate
Dopamine and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses dopamine causes vasoconstriction and may oppose the antihypertensive effect of hydralazine. Combined use can lead to unpredictable blood pressure and heart rate changes.
What this interaction means in plain words
Dopamine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Hydralazine belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism between dopamine-induced adrenergic vasoconstriction and hydralazine vasodilation.
What to do
Monitor blood pressure, heart rate and urine output while titrating dopamine. Adjust hydralazine dosing to hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Frequently asked questions
Can I take Dopamine with Hydralazine?
MediHelp rates the interaction as moderate. Dopamine and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses dopamine causes vasoconstriction and may oppose the antihypertensive effect of hydralazine. Combined use can lead to unpredictable blood pressure and heart rate changes.
How serious is the interaction between Dopamine and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and urine output while titrating dopamine. Adjust hydralazine dosing to hemodynamic response.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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