Drug interactions
Dopamine + Imipramine
Severity: Major
Dopamine and Imipramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine can enhance pressor and arrhythmogenic responses to sympathomimetic amines through reuptake blockade. Dopamine may therefore cause exaggerated hypertension or arrhythmia.
What this interaction means in plain words
Dopamine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dopamine belongs to Cardiovascular; Imipramine belongs to Central Nervous System.
Why it happens
Inhibition of neuronal norepinephrine reuptake alters response to dopamine.
What to do
Start dopamine at a reduced dose and titrate with continuous hemodynamic and ECG monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dopamine with Imipramine?
MediHelp rates the interaction as major. Dopamine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imipramine can enhance pressor and arrhythmogenic responses to sympathomimetic amines through reuptake blockade. Dopamine may therefore cause exaggerated hypertension or arrhythmia.
How serious is the interaction between Dopamine and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dopamine at a reduced dose and titrate with continuous hemodynamic and ECG monitoring.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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