Drug interactions
Dopamine + Rasagiline
Severity: Major
Dopamine and Rasagiline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline inhibits MAO-B, and at higher doses loses selectivity, which can reduce dopamine metabolism and enhance the pressor response to dopamine. A hypertensive episode is possible.
What this interaction means in plain words
Dopamine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dopamine belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition decreases dopamine degradation, potentiating its sympathomimetic effect.
What to do
Start dopamine at a substantially lower dose and titrate slowly with continuous blood pressure monitoring. Consider an alternative vasopressor if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dopamine with Rasagiline?
MediHelp rates the interaction as major. Dopamine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rasagiline inhibits MAO-B, and at higher doses loses selectivity, which can reduce dopamine metabolism and enhance the pressor response to dopamine. A hypertensive episode is possible.
How serious is the interaction between Dopamine and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dopamine at a substantially lower dose and titrate slowly with continuous blood pressure monitoring. Consider an alternative vasopressor if feasible.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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