Drug interactions
Dopexamine + Lisdexamfetamine
Severity: Moderate
Dopexamine and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is an intravenous catecholamine-like agent with beta-2 and dopaminergic activity, and lisdexamfetamine is a sympathomimetic stimulant. Together they may increase heart rate, cause arrhythmias and alter blood pressure. Dopexamine is used in monitored hospital settings.
What this interaction means in plain words
Dopexamine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects; amphetamine releases catecholamines and dopexamine stimulates adrenergic and dopamine receptors.
What to do
Monitor heart rate, rhythm and blood pressure continuously during dopexamine infusion. Consider withholding lisdexamfetamine in acutely ill patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dopexamine with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Dopexamine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine is an intravenous catecholamine-like agent with beta-2 and dopaminergic activity, and lisdexamfetamine is a sympathomimetic stimulant. Together they may increase heart rate, cause arrhythmias and alter blood pressure. Dopexamine is used in monitored hospital settings.
How serious is the interaction between Dopexamine and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure continuously during dopexamine infusion. Consider withholding lisdexamfetamine in acutely ill patients.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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