Drug interactions
Doravirine + Isoniazid
Severity: Minor
Doravirine and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doravirine is a CYP3A substrate, so CYP3A inhibitors can raise its levels. Isoniazid is only a weak CYP3A inhibitor, and doravirine has a wide safety margin, so a clinically important increase is unlikely.
What this interaction means in plain words
Doravirine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doravirine belongs to Anti Virals; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak inhibition of CYP3A4 by isoniazid may slightly reduce doravirine clearance.
What to do
No dose adjustment is needed. Use routine monitoring for doravirine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Doravirine
- Amobarbital + Doravirine Contraindicated
- Apalutamide + Doravirine Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Doravirine + Efavirenz Contraindicated
- Doravirine + Enzalutamide Contraindicated
- Doravirine + Mitotane Contraindicated
Frequently asked questions
Can I take Doravirine with Isoniazid?
MediHelp rates the interaction as minor. Doravirine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doravirine is a CYP3A substrate, so CYP3A inhibitors can raise its levels. Isoniazid is only a weak CYP3A inhibitor, and doravirine has a wide safety margin, so a clinically important increase is unlikely.
How serious is the interaction between Doravirine and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Use routine monitoring for doravirine adverse effects.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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