Drug interactions
Dosulepin + Estradiol
Severity: Minor
Dosulepin and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise tricyclic antidepressant exposure, which can intensify anticholinergic, sedative and cardiac adverse effects of dosulepin. Some patients may also show a reduced antidepressant response. The evidence is limited and mostly from older reports.
What this interaction means in plain words
Dosulepin and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dosulepin belongs to Central Nervous System; Estradiol belongs to Endocrine.
Why it happens
Proposed reduction in hepatic metabolism of the tricyclic by estrogen; the mechanism is not firmly established.
What to do
Monitor for tricyclic adverse effects and antidepressant response when estrogen therapy is started or stopped. Adjust the dosulepin dose according to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Estradiol?
MediHelp rates the interaction as minor. Dosulepin and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may raise tricyclic antidepressant exposure, which can intensify anticholinergic, sedative and cardiac adverse effects of dosulepin. Some patients may also show a reduced antidepressant response. The evidence is limited and mostly from older reports.
How serious is the interaction between Dosulepin and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and antidepressant response when estrogen therapy is started or stopped. Adjust the dosulepin dose according to clinical response.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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